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Electrical coupling regulated by GABAergic nucleo-olivary afferent fibres facilitates cerebellar sensory–motor adaptation
The inferior olivary (IO) nucleus makes up the signal gateway for several organs to the cerebellar cortex. Located within the …
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Computational epidemiology study of homeostatic compensation during sensorimotor aging
The vestibulo-ocular reflex (VOR) stabilizes vision during head motion. Age-related changes of vestibular neuroanatomical properties …
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A cerebellar-based solution to the nondeterministic time delay problem in robotic control
The presence of computation and transmission-variable time delays within a robotic control loop is a major cause of instability, …
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A Basal Ganglia Computational Model to Explain the Paradoxical Sensorial Improvement in the Presence of Huntington’s Disease
The basal ganglia (BG) represent a critical center of the nervous system for sensorial discrimination. Although it is known that …
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Optimization of Efficient Neuron Models With Realistic Firing Dynamics. The Case of the Cerebellar Granule Cell
Biologically relevant large-scale computational models currently represent one of the main methods in neuroscience for studying …
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Simulation, visualization and analysis tools for pattern recognition assessment with spiking neuronal networks
Computational modeling is becoming a widely used methodology in modern neuroscience. However, as the complexity of the phenomena under …
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An integrative methodology based on protein-protein interaction networks for identification and functional annotation of disease-relevant genes applied to channelopathies
Background. Biologically data-driven networks have become powerful analytical tools that handle massive, heterogeneous datasets …
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On robot compliance. A cerebellar control approach
The work presented here is a novel biological approach for the compliant control of a robotic arm in real time (RT). We integrate a …
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Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation
Cerebellar Purkinje cells mediate accurate eye movement coordination. However, it remains unclear how oculomotor adaptation depends on …
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VOR Adaptation on a Humanoid iCub Robot Using a Spiking Cerebellar Model
We embed a spiking cerebellar model within an adaptive real-time (RT) control loop that is able to operate a real robotic body (iCub) …
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